What is the most important information I should know about Motrin?

• Take Motrin with food, milk, or an antacid to lessen stomach upset.
• Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.
• Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Motrin (such as naproxen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.
• Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Motrin may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Motrin if you drink more than 3 alcoholic beverages a day.

What is Motrin?

• Motrin is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Motrin works by reducing hormones that cause inflammation and pain in the body.
• Motrin is used to reduce the fever, pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation.
• Motrin may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Motrin?

• Before taking Motrin, tell your doctor if you
  • have an allergy to aspirin or any other NSAIDs,
  • have an ulcer or bleeding in the stomach,
  • drink more than three alcoholic beverages a day,
  • have liver or kidney disease,
  • have a coagulation (bleeding or blood clotting) disorder,
  • have congestive heart failure,
  • have fluid retention,
  • have heart disease, or
  • have high blood pressure.
• You may not be able to take Motrin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
• During the first two trimesters of pregnancy Motrin is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby during the first two trimesters of pregnancy. However, Motrin should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take Motrin without first talking to your doctor if you are pregnant or could become pregnant during treatment.
• Motrin passes into breast milk in very small amounts, however it is not expected to be harmful to a nursing baby. Talk to your doctor before taking Motrin if you are breast-feeding.

How should I take Motrin?

• Take Motrin exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you
• Take each dose with a full glass of water.
• Take Motrin with food, milk, or an antacid to lessen stomach upset.
• Shake the suspension well before measuring a dose. To ensure that you get the correct dose, measure the liquid form of Motrin with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
• Store Motrin at room temperature away from moisture and heat.

What happens if I miss a dose?

• If you are taking Motrin on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.
• If you are taking Motrin as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.

What happens if I overdose?

• Seek emergency medical attention if an overdose is suspected.
• Symptoms of a Motrin overdose may include nausea, vomiting or stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

What should I avoid while taking Motrin?

• Avoid prolonged exposure to sunlight. Motrin may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.
• Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Motrin may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Motrin if you drink more than 3 alcoholic beverages a day.
• Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Motrin (such as naproxen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

What are the possible side effects of Motrin?

• Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.
• If you experience any of the following serious side effects, stop taking Motrin and seek medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • muscle cramps, numbness, or tingling;
  • ulcers (open sores) in the mouth;
  • rapid weight gain (fluid retention);
  • seizures;
  • decreased hearing or ringing in the ears;
  • yellowing of the skin and eyes (jaundice); or
  • abdominal cramping, indigestion, or heartburn.
• Other, less serious side effects may be more likely to occur. Continue to take Motrin and talk to your doctor if you experience
  • dizziness or headache;
  • nausea, gaseousness, diarrhea, or constipation;
  • depression;
  • fatigue or weakness;
  • dry mouth; or
  • irregular menstrual periods.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Motrin?

• Before taking Motrin, tell your doctor if you are taking any of the following drugs:
  • aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others);
  • another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Anaprox, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
  • an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, Motrin, Motrin, or ketoprofen;
  • an anticoagulant (blood thinner) such as warfarin (Coumadin);
  • a steroid such as prednisone (Deltasone);
  • insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others;
  • probenecid (Benemid);
  • lithium (Eskalith, Lithobid, others); or
  • bismuth subsalicylate in drugs such as Pepto-Bismol.
• You may not be able to take Motrin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with Motrin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.